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Travel Vaccinations for South Africa

Which vaccines do I need?


Certificate Requirements

You need a yellow fever certificate when entering South Africa if you have previously passed through a country where there is a risk of yellow fever transmission. This includes Eritrea, Sao Tome and Principe, Somalia, Tanzania and Zambia. The same applies if you have changed flights at the airport of a yellow fever country and spent more than 12 hours at the airport. Only adults and children over the age of 1 year are required to show a yellow fever certificate.

How much will it cost?

Per Dose £60
Doses per course 1
Price per course £60

Recommended for all travellers

The vaccines in this section are recommended for all travellers visiting the country.

If you have grown up in the UK, you have most likely received a diphtheria vaccine as a part of your routine childhood vaccinations. Before you go abroad you should check whether you require a booster to avoid medical emergencies.

How much will it cost?

Per Dose £32
Doses per course 1
Price per course £32

The hepatitis A vaccine is important for all travellers visiting South Africa. Although the disease can pass without causing symptoms it can also cause jaundice and liver damage. The exact scale of hepatitis A infections in South Africa is unknown. According to recent studies, however, the majority of adults in South Africa carry hep A antibodies, which means that they have been exposed to the virus at some point in the past.

How much will it cost?

Per Dose £55
Doses per course 1
Price per course £55

Recommended for some travellers

Whether you will need any of the vaccines in this section depends on the region you're travelling to, the activities you have planned and your medical history.

Cholera is a bacterial infection, which causes diarrhoea and vomiting. Quick treatment is essential, as the illness can be fatal if untreated. Despite efforts to reduce the incidence of cholera in South Africa by introducing vaccinations and improving public awareness of the infection, outbreaks may still occur. The last major cholera outbreak in South Africa in 2000 led to 86107 reported cases and claimed 181 lives. Whether you require the cholera vaccination depends on where you are travelling - the risk of food- and waterborne diseases is higher in areas with a poor sanitation system.

How much will it cost?

Per Dose £28
Doses per course 2
Price per course £56

Hepatitis B is very common in South Africa, with an estimated 10 - 18% of adults in South Africa suffering from the disease. The infection is particularly widespread in the Eastern Cape Province and Kwazulu-Natal. The hep B virus is transmitted during sexual intercourse and when sharing needles. Although transmitted in a similar way as the HIV virus, it is far more contagious and passed on more easily. The vaccine is recommended for healthcare professionals and aid workers as well as everyone who is likely to engage in close contact with the local population. Be careful with getting tattoos or piercings abroad to avoid exposure to the virus. Your local travel nurse can help you decide whether you require the vaccination.

How much will it cost?

Per Dose £45
Doses per course 3
Price per course £135

Every year, there are 10 to 30 reported cases of rabies in humans in South Africa, primarily in the north-eastern regions of the East Cape. In most cases, the disease is transmitted by dogs. The rabies vaccine is important for anyone likely to come in close contact with wildlife or domestic animals while abroad. It may also be necessary if you are planning to travel to remote areas where medical help is not readily available. The rabies vaccine extends the period of time during which the post exposure rabies treatment is effective - you still need to get treated if you get bitten. Once the infection has broken out, it is almost always fatal.

How much will it cost?

Per Dose £58
Doses per course 3
Price per course £174

Tetanus is a bacterial infection which usually occurs following an injury such as a cut, wound or a graze. The tetanus vaccination is included in the standard vaccine schedule and it is routinely given to children in the UK. Before you travel you should check whether you need a booster to maintain immunity.

How much will it cost?

Per Dose £32
Doses per course 1
Price per course £32

Typhoid is a food- and waterborne infection which primarily occurs in areas with a poor sanitation system and low levels of awareness with regards to hygiene. It usually causes symptoms such as diarrhoea or constipation as well as stomach pain and a high fever. Patients usually respond well to antibiotic treatment if treated soon after experiencing the first symptoms. If left untreated, typhoid can be fatal. You should consider getting vaccinated if you will be spending time in remote areas with a poor infrastructure and limited access to medical care.

How much will it cost?

Per Dose £32
Doses per course 1
Price per course £32

Why do I need a consultation?

It is difficult to say which vaccines you need without asking a medical professional. Your itinerary, your medical history and the activities you have planned all affect which vaccinations you need. It is important that a trained travel nurse or pharmacist checks what you need.

Exactly the travel vaccinations you need - no more, no less.

During your consultation, our nurse or pharmacist will talk you through the health risks at your travel destinations to check which vaccines you need. If a vaccine is not essential, we will explain your options so you can decide whether you would like to have it.


Malaria is a serious and sometimes fatal disease transmitted by mosquitoes. You cannot be vaccinated against malaria.

Malaria Precautions

South Africa is a risk country for malaria. There is a risk of infection all year round but the risk is particularly high from September to May. You are unlikely to contract malaria in areas of high altitude, but low altitude areas of Mpumalanga Province (including Kruger National Park) and Limpopo Province that borders Mozambique, Estwatini (Swaziland) and Zimbabwe, have a moderate risk of malaria. If you are travelling to a risk area you need to take antimalarial tablets in addition to using insect repellent and avoiding mosquito bites.

There is a low risk of malaria in northeastern parts of the KwaZulu-Natal province and in some parts of the Mpumalanga, Limpopo and Northern Cape Provinces.

Travellers who are planning long trips, to stay in remote areas without access to local medical facilities may be advised to also take a malaria treatment for acute bouts of the disease with them, in case the preventative treatment fails.

Your Superdrug nurse or pharmacist will assess your need for an antimalarial based on your medical history and itinerary.

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Book an appointment

Book online or call our booking line. Our lines are open every day!

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Free Consultation

During your appointment, the nurse or pharmacist will assess which vaccines or medications you need.

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Get your treatment

Once our health advisor has assessed your needs, you'll receive your vaccinations & treatments straight away.

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